HEPATOCARCINOGENESIS BY PEROXISOME PROLIFERATORS
نویسندگان
چکیده
منابع مشابه
Perplexing peroxisome proliferators.
Soft agarose culture human tumour colony forming assay for drug sensitivity testing: [3H]-Thymidine incorporation vs colony counting Summary In vitro drug sensitivity testing, both by optical colony counting and by a [3H]-TdR incorporation assay, was performed on human tumour cells proliferating in soft agar cultures. Cells from two different human tumour cell lines, 5 different human tumour xe...
متن کاملExcessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators.
Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes and enhance the activ ities of peroxisome-associated enzymes in the livers of rodents. Evidence now suggests that potent hepatic peroxisome proliferators as a class are carcinogenic, although they do not appear to be mutagenic in the Sa/mor>e//a-microsome assay system. We now report that long-ter...
متن کاملPeroxisome proliferation and hepatocarcinogenesis.
Peroxisome proliferators constitute a novel class of non-mutagenic hepatocarcinogens, all of which induce a similar pleiotropic response consisting of hepatomegaly, proliferation of peroxisomes in the liver parenchyma] cells and the induction of several hepatic enzymes, particularly those of the peroxisomal fatty acid /3oxidation system (1—3). Presently several structurally dissimilar hypolipid...
متن کاملPeroxisome proliferators activate Kupffer cells in vivo.
The mechanism by which peroxisome proliferators increase cell replication and cause liver tumors in rodents remains unknown. When activated, Kupffer cells, the resident hepatic macrophages, release a variety of mitogenic stimuli that could theoretically increase cell proliferation in nearby hepatocytes. Therefore, in the present study we evaluated the effect of two potent peroxisome proliferato...
متن کاملNon-genotoxic hepatocarcinogenesis in vitro: the FaO hepatoma line responds to peroxisome proliferators and retains the ability to undergo apoptosis.
A range of hepatoma cell lines (RH1, HTC, FaO, 7800C1 and MH1C1), has been studied with the aim of establishing an in vitro model to investigate the molecular mechanisms of hepatocarcinogenicity induced by the peroxisome proliferator class of non-genotoxic carcinogens. In view of speculation that peroxisome proliferators suppress hepatocyte apoptosis in vivo, we have placed particular emphasis ...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2004
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.29.1